Recombinant, expressed in Escherichia coli (E.coli)
This recombinant human interleukin-2 (rhIL-2, Aldesleukin) is an immunomodulatory cytokine with a molecular weight of approximately 15 kDa. Aldesleukin differs from the natural Interleukin-2: Aldesleukin does not have an N-terminal alanine, the amino acid cysteine at position 125 is substituted by serine and the molecule is not glycosylated. The biological activity of the recombinant IL-2 is similar to that of the native human IL- 2. Interleukin-2 is important for proliferation of T and B lymphocytes and stimulates differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.